Santa Fe, Texas Real Estate Santa Fe, Texas is a small town in Galveston County, Texas. The town was formed after the Santa Fe Railway was built alongside State Highway 6 in 1877. As of the Census of 2000 Santa Fe has a population of 9,548 and a total area of 14 square miles according to the United States Census Bureau. There are many types of housing available in Santa Fe including condominiums, apartments, old homes, custom homes, and new homes.
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